P432 ARTERIAL STIFFNESS AND CARDIOVASCULAR RISK IN PATIENTS WITH NEPHROLITIASIS: A 10–YEAR PROSPECTIVE STUDY

Abstract Nephrolithiasis is frequently associated with several cardiovascular diseases, and the pathophysiological connection may rely on some common risk factors. In fact, systemic inflammation, promoting oxidative stress, lead to arterial wall stiffening (which considered an independent predictor of risk); however, same mechanism also play a role in Randall’s plaques deposition, which predisposing step nephrolithiasis. This study aims examine correlation between stiffness nephrolithiasis, exploring its trend across aging. 82 patients (mean age 45±13 years, 36 males) referred Geriatrics Nephrology Outpatient Clinic were prospectively enrolled: at baseline after 10 years they underwent clinical evaluation (with particular focus events factors), measurement, obtaining carotid–femoral Pulse Wave Velocity (PWVcf) by applanation tonometry. 66 diagnosed whereas remaining 16 formed control group. At baseline, compared group, nephrolithiasis showed higher systolic blood pressure PWVcf (128±18 vs 117±16 mmHg, p 0.02 7.78±1.53 6.50±1.13 m/s, 0.001 respectively). After (p 0.001), but not without 0.081), had significant raise PWVcf, as (10.64±3 7.78±1.55 m/s); this was confirmed even adjustment for sex. backward regression model, considering variation over follow up (ΔPWVcf) dependent variable, age, sex, Δ mean pressure, Body Mass Index, hypertension variables, proved be only ΔPWVcf, accounting 6.9% variance 0.027). conclusion, present outlines increased affected represented wider increase ΔPWVcf within years. These findings endorse comprehensive subjects moving beyond nephrological condition, patient’s profile, identify, prevent or treat any possible organ damage.